10 warning signals of cancer

Stem Cell Era - Novel Knee Repair (part 2)

Dr Lee believes his method will be less traumatic for patients, saying:'It's minimally invasive, with very small holes, not a big cut, so there will be less pain and where there is less pain, patients also recover faster'

Active people in their 40s are no longer puting up with the pain and immobility caused be damaged cartilage in their knees. They are instead checking into hospitals to get their problem surgical fixed. The operation, an autologous cartilage transplant, involves harvesting a small amount of their cartilage or connective tissue, growing this in a laboratory til there are millions of cells, and then implanting this is their bad knees.

The National University Hospital (NUH) Singapore has done more than 100 such transplants since 2000. Demand for this treatment is growing, with twoor three operations done every month here.

The surgery is like having an infusion of fresh cartilage to patch up 'potholes' in the tissue, which could have come from contact sports or other injuries. The patient's pain from this problem comes from the holes leaving nerve ends in the bone exposed. Patients are always given painkiller as the first line of treatment. But if these do not work, and the person wishes to continue playing sports, an aoutologues transplant cartilage is now a viable option. Since the cartilage is harvested from the patient himself, the risk of rejection is zero. However, this is not a treatment surgeons offer older people, who mostly given total knee replacements.

Source: National University Hospital - Singapore, September 2009

Stem Cell Era - Novel Knee Repair (part 1)

An experimental procedure to repair knee cartilage using Stem Cells has brought relief to 35 people here in last three years.

Now, Dr Kevin Lee from the division of adult reconstructive surgery at the National University Hospital, hopes to test into 100 patients over the next two years to see if it is better than current methods. His method marries two techniques used in other parts of the world, but with some modifications.

Dr Lee's method, a day-surgery procedure that lasts about 1 1/2 hours, involves making holes with a tiny pick, through keyhole surgery, in the bone of a patient's knee which has been worn out by overuse. This release a type of stem cell from bone marrow, which later grows into cartilage cells. At the same time, he extracts bone marrow from an area near the hip. This is done to obtain stem cells. a type of master cell which can be grown into bone, fat or cartilage.

Three weeks later, the few hundred stem cells would have grown into over 10 million adult stem cells. These are injected into the patient's knee, together with a fluid which protects the cartilage cells from damage. The stem cells are able to home in on the area where there is missing cartilage. These cells then either become cartilage cells themselves or stimulate surrounding cells to become cartilage cells. It takes few weeks for the stem cells to become cartilage cells and at least six months before the cells become mature cartilage.

Civil servant Wahida Mansor, 44, could climb the 12 storeys to her Jurong West flat several months after the procedure. The mother of three said:'In the past, after walking for few hours, my knees would swell and it would be very uncomfortable. I was unable to sleep. Now I still can't jog, but at least I can sleep and do housework because it's not painful and doesn't swell.

About 150 to 200 cartilage operations are done in Singapore a year. They are done by extracting cartilage cells, growing them in the lab and opening up the knee to transplant them.
An Orthopaedic surgeon ar Mount Elizabeth Medical Centre, Dr Yegappan Muthukaruppan, does about 10 such operation a year. Commenting on Dr Lee's method, he said: 'This is experimental currently, but I do believe this will be the way to go as it is minimally invasive'

KESAKSIAN DI NATIONAL UNIVERSITY HOSPITAL, SINGAPURA

Bulan Juni 2009 saya membawa anak saya (Sami) ke singapura (NUH, National University Hospital) karena diduga sakit leukemia. Leukositnya 43.000.

Saya ke dokter Allan bag cancer leukemia, menurut analisannya Sami tidak kena leukemia.

Saya puas atas analisanya, dokter dan susternya pun ramah2.


Trims ya

Mengapa Kolesterol bisa tinggi? Berapa Kadar Kolesterol Ideal?

Banyak faktor yang mempengaruhi kadar kolesterol dalam darah. Sebagian faktor tidak bisa dirubah, tapi banyak yang bisa kita kontrol.

Faktor yang tidak bisa dirubah:
  • Keturunan
Jumlah LDL yang dibentuk tubuh dan sebarapa cepat LDL dibuang sangat ditentukan oleh gen seseorang.
Sebagian orang memiliki LDL tinggi hanya disebabkan karena faktor keturunan, bukan oleh faktor resiko lainnya.

  • Umur dan Jenis Kelamin
Kolesterol darah mulai meningkat pada usia 20 dan terus meningkat sampai usia 60 - 65.
Sebelum usia 50, total kolesterol pada pria lebih tinggi dibanding wanita pada usia yang sama, tetapi kondisi ini berbalik setelah usia 50. Karena wanita mengalami menopause, LDL seringkali meningkat.

Faktor yang bisa dikontrol:
  • Diet / Pengaturan makan
Ada 3 jenis makanan yang meningkatkan kadar LDL
1.
Lemak jenuh (Saturated fat), ditemukan pada makanan yang diproses dengan lemak yang berasal dari binatang
2.
Lemak trans (trans fat), ditemukan pada makanan yang diproses dengan minyak hidrogenasi seperti margarine, crackers dan kentang goreng
3.
Kolesterol, berasal dari produk binatang

Lemak jenuh meningkatkan kadar LDL lebih dari makanan yang lain.

  • Overweight / kegemukan
Kelebihan berat badan meningkatkan kadar LDL, meningkatkan trigliserida dan menurunkan kadar HDL (kolesterol 'baik')

  • Kurang Gerak
Kurang bergerak akan berdampak pada kegemukan, meningkatkan LDL dan menurunkan HDL.
Olahraga teratur dapat meningkatkan HDL dan menurunkan kadar Trigliserida.


KADAR KOLESTEROL IDEAL
Total Kolesterol
Kurang dari 200 mg/dL diharapkan
200 - 239 mg/dL batas atas
giLebih dari 240 mg/dL tinggi

Kolesterol LDL
Kurang dari 100 mg/dL optimal
100 - 129 mg/dL diatas optimal
130 - 159 mg/dL batas atas
160 - 189 mg/dL tinggi
Lebih dari 190 mg/dL sangat tinggi

Kolesterol HDL
Kurang dari 40 mg/dL sangat beresiko terkena serangan jantung
Lebih dari 60 mg/dL memberikan perlindungan terhadap serangan jantung